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Parenteral Nutrition Complications in Children Undergoing Bone Marrow Transplantation

Mohamed A Soussi1,2, Habib Besbes3,4, Fethi Mellouli5

  • 1Pharmacy Department.

Journal of Pediatric Hematology/Oncology
|July 16, 2019
PubMed

Insights

Parenteral nutrition (PN) caused numerous complications in children undergoing bone marrow transplants. Duration of PN, age, and hyperglycemia were identified as key risk factors for these adverse events.

Area of Science:

  • Pediatric Hematology
  • Transplant Medicine
  • Clinical Nutrition

Background:

  • Parenteral nutrition (PN) is utilized to manage nutritional deficits in bone marrow transplant (BMT) patients.
  • However, PN may be associated with significant complications in this vulnerable population.

Purpose of the Study:

  • To document PN-related complications in pediatric allogeneic BMT recipients.
  • To identify independent risk factors contributing to these complications.

Main Methods:

  • Retrospective observational study of 51 pediatric patients (2-17 years) undergoing allogeneic BMT.
  • Medical records were reviewed to identify and assess PN-related complications using a causality method.
  • Multivariate analysis was employed to determine independent risk factors.

Main Results:

  • A high incidence of PN-related complications was observed, with 92% of patients experiencing a total of 136 events.
  • Infectious complications (32.3%) and electrolyte imbalances (27.9%) were most frequent.
  • Risk factors identified included duration of PN, patient age, and hyperglycemia.

Conclusions:

  • PN is associated with substantial complications in pediatric BMT patients.
  • Enteral nutrition should be prioritized in BMT protocols to mitigate PN-related risks.
Abstract

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