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Related Experiment Video

Updated: Jan 22, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

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Borderline-Positive Quantiferon in Children.

Ulrikka Nygaard¹, Anja Poulsen¹, Alex Yde Nielsen²

¹Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.

The Pediatric Infectious Disease Journal

|July 16, 2019

Summary

This summary is machine-generated.

Retesting borderline results for Quantiferon (interferon-gamma release assay) in children showed high variability. Most borderline results became negative upon retesting, suggesting potential false positives in initial tuberculosis screening.

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Area of Science:

Pediatric Infectious Diseases
Immunology
Tuberculosis Diagnostics

Background:

Quantiferon testing is used for tuberculosis screening.
Borderline results require careful interpretation due to potential variability.

Purpose of the Study:

To assess the reproducibility of borderline Quantiferon results in children.
To determine the rate of false positives in initial borderline Quantiferon tests.

Main Methods:

Systematic retesting of children with borderline-positive Quantiferon results (0.35-0.99 IU/mL) between 2015-2019.
Analysis of 647 tests, identifying 27 positive results and 10 borderline-positive results.

Main Results:

10 of 27 (37%) positive Quantiferon tests were initially borderline.
90% (9 of 10) of these borderline results became negative upon retesting.
Children under 5 years old with borderline results consistently tested negative on tuberculin skin tests.

Conclusions:

High test variability exists for borderline Quantiferon results in children.
A significant proportion of borderline Quantiferon results may represent false positives.
Further investigation is warranted for borderline Quantiferon results, especially in young children.