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Cutaneous Bone Formation Associated With Melanocytic Nevus
1Baskent University, Medicine Faculty, Pathology Department.
The Journal of Craniofacial Surgery
|July 16, 2019
Summary
Cutaneous bone formation in melanocytic nevi is rare, predominantly affecting females on the face. This study suggests a link between acne, inflammation, and bone formation in these skin lesions.
Area of Science:
- Dermatopathology
- Skeletal Biology
- Cutaneous Oncology
Background:
- Cutaneous bone formation, or extraskeletal ossification, is an uncommon dermatologic finding.
- Secondary cutaneous bone formation is frequently associated with melanocytic nevi.
- The exact etiology of extraskeletal bone formation remains poorly understood.
Purpose of the Study:
- To describe the clinicopathologic features of melanocytic nevi with cutaneous bone formation.
- To investigate potential associations and distinguishing characteristics of these lesions.
Main Methods:
- A retrospective analysis of 20 patients with melanocytic nevi with or without osseous metaplasia was conducted.
- Histologic and clinicopathologic data, including age, sex, lesion location, focus number, and size, were collected and compared.
Main Results:
- Lesions were more prevalent in 10 female patients, primarily located on the head and neck (face, forehead, eyebrow, lip, neck).
- Most lesions were solitary, often associated with a single focus of ossification.
- Fifty percent of patients reported a history of acne and its treatment; granulomatous dermal inflammation was observed in two cases.
Conclusions:
- Melanocytic nevi with cutaneous bone formation exhibit distinct features, including a predilection for females and facial location, and a frequent association with acne history.
- Inflammatory-induced metaplastic ossification may play a role, potentially linked to osteogenic factors and female sex.
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