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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture

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Published on: April 10, 2020

Persistent Digermenes with Acyl and α-Chlorosilyl Functionalities.

Lukas Klemmer¹, Yvonne Kaiser¹, Volker Huch¹

¹Krupp Chair of General and Inorganic Chemistry, Saarland University, 66123, Saarbrücken, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|July 16, 2019

Summary

This summary is machine-generated.

Researchers synthesized novel digermenes with a germanium-germanium double bond. These compounds exhibit unique stability and reactivity, unlike transient disilenes, offering new avenues in organometallic chemistry.

Keywords:

cycloaddition digermenes double bonds germanium isomerization

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Area of Science:

Organometallic Chemistry
Silicon and Germanium Chemistry

Background:

Digermenes, compounds featuring a germanium-germanium double bond (Ge=Ge), are typically transient and reactive species.
Understanding the stability and reactivity of digermenes is crucial for advancing organometallic chemistry.

Purpose of the Study:

To synthesize and characterize novel α-chlorosilyl- and acyl-substituted digermenes.
To investigate the stability, reactivity, and structural properties of these digermenes compared to disilenes.

Main Methods:

Synthesis of α-chlorosilyl- and acyl-substituted digermenes.
Isolation and characterization of triphenylsilyldigermene as a crystalline model compound.
Spectroscopic and computational analyses to determine the structure of 1-adamantoyldigermene.

Main Results:

The synthesized digermenes show a low tendency for cyclization, contrasting with transient disilenes.
These digermenes are prone to thermal cleavage of the Ge=Ge bond.
Triphenylsilyldigermene represents the first fully characterized neutral digermene with an A₂GeGeAB substitution pattern.
1-adamantoyldigermene is the first persistent digermene featuring a heavy double bond conjugated with a carbonyl group.

Conclusions:

Novel substituted digermenes can be synthesized and characterized.
These digermenes exhibit distinct stability and reactivity profiles compared to disilenes.
The findings open new possibilities for utilizing digermenes in synthetic chemistry.