Dupilumab and alopecia: A Janus effect
Cataldo Patruno1, Maddalena Napolitano2, Maria Ferrillo3
1Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Abstract:
Atopic dermatitis (AD) and alopecia areata (AA) are two common skin diseases that can coexist in the same patient, sharing some pathogenetic mechanisms such as the overexpression of interleukin 4 (IL4) and interleukin 13 (IL13). Recently, cases of AA healing during treatment with anti-IL4/IL13 monoclonal antibody dupilumab (D) for AD were reported. However, cases of appearance of AA have been described during D treatment too. We report two patients that experienced these two opposite effects of D.
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