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Updated: Jan 22, 2026
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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Predicting Short-term Outcomes After Radical Cystectomy Based on Frailty
Joaquin Michel1, Alexander N Goel2, Vishnukamal Golla1
1Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Urology
|July 16, 2019
Summary
Frailty significantly increases adverse outcomes for bladder cancer patients undergoing radical cystectomy, including higher mortality and costs. Preoperative frailty assessment is crucial for better patient care and decision-making.
Area of Science:
- Urology
- Oncology
- Geriatrics
Background:
- Radical cystectomy is a major surgery for bladder cancer.
- Patient frailty is increasingly recognized as a risk factor for surgical outcomes.
Purpose of the Study:
- To assess the impact of frailty on adverse perioperative outcomes in patients undergoing radical cystectomy for bladder cancer.
Main Methods:
- Analysis of 9459 adult patients from the Nationwide Readmission Database who underwent radical cystectomy in 2014.
- Frailty status determined using the Johns Hopkins Adjusted Clinical Groups frailty-defining diagnosis indicator.
- Comparison of outcomes between frail and nonfrail groups using statistical tests and multivariate logistic regression.
Main Results:
- 7.1% of patients were identified as frail.
- Frail patients had significantly higher rates of in-hospital mortality, ICU complications, and nonhome discharge.
- Frail patients experienced longer hospital stays and higher costs compared to nonfrail patients.
- Frailty was the strongest predictor for several adverse outcomes.
Conclusions:
- Frail patients undergoing radical cystectomy face a higher likelihood of adverse perioperative outcomes.
- Preoperative frailty assessment can aid clinical guidance and shared decision-making for these patients.
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