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Functional network connectivity changes in children with attention-deficit hyperactivity disorder: A resting-state
Kaihua Jiang1, Yang Yi1, Lin Li1
1Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou, 213003, China.
Summary
Attention-deficit hyperactivity disorder (ADHD) involves altered brain network connectivity. Resting-state fMRI revealed distinct patterns in brain regions for children with ADHD compared to controls.
Area of Science:
- Neuroscience
- Medical Imaging
- Developmental Psychology
Background:
- Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
- Understanding the neural mechanisms of ADHD is crucial for effective diagnosis and treatment.
- Previous research suggests alterations in brain structure and function in ADHD.
Purpose of the Study:
- To investigate the pathological mechanisms of functional brain regions in ADHD.
- To compare brain network properties between children with and without ADHD.
- To utilize resting-state functional magnetic resonance imaging (fMRI) to analyze brain network nodes and interhemispheric functional connectivity.
Main Methods:
- Recruited 35 children diagnosed with ADHD and 42 healthy children.
- Acquired resting-state fMRI data from all participants.
- Analyzed brain data using Degree Centrality (DC) and Voxel-Mirrored Homotopic Connectivity (VMHC) methods.
Main Results:
- ADHD group showed decreased DC values in several frontal and parietal regions compared to controls.
- Increased DC values were observed in the cerebellar anterior lobe and cingulate gyrus in ADHD patients.
- VMHC analysis indicated higher connectivity in bilateral frontal, occipital, and cerebellar regions in children with ADHD.
Conclusions:
- The study highlights significant differences in brain network organization between children with and without ADHD.
- DC and VMHC analyses provide a comprehensive and cross-checkable approach to understanding ADHD neural mechanisms.
- Findings contribute to a deeper understanding of the neurobiological underpinnings of ADHD.
Keywords:
Attention-deficit hyperactivity disorderChildrenDegree centralityResting-state functional magnetic resonance imagingVoxel-mirrored homotopic connectivityMore Related Videos
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