Related Experiment Video
Updated: Jan 22, 2026

Patch-Clamp Techniques for Single Endolysosomal Vesicle Analysis
Published on: April 4, 2025
Modified-Single Patch vs Double Patch Repair of Complete Atrioventricular Septal Defects.
Laura S Fong1, Kim Betts2, Raviteja Kannekanti3
1Discipline of Child and Adolescent Health, Faculty of Health and Medicine, The University of Sydney, Sydney, Australia; Heart Centre for Children, The Children's Hospital at Westmead, Westmead, Australia.
Biventricular repair of complete atrioventricular septal defect (CAVSD) using double-patch (DP) or modified single-patch (MSP) techniques shows similar long-term event-free survival. Both DP and MSP are safe and effective for CAVSD repair, with specific risk factors identified for reoperation and mortality.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Congenital Heart Disease
Background:
- Complete atrioventricular septal defect (CAVSD) repair is crucial for pediatric cardiac patients.
- The double-patch (DP) and modified single-patch (MSP) techniques are current standards for biventricular repair.
- Long-term outcomes of the MSP technique for CAVSD repair require further definition.
Purpose of the Study:
- To compare long-term outcomes, including reoperation and mortality, after DP versus MSP repair of CAVSD.
- To identify risk factors associated with adverse outcomes following CAVSD repair.
- To evaluate the safety and efficacy of both DP and MSP techniques in CAVSD biventricular repair.
Main Methods:
- Retrospective cohort study of 273 patients undergoing CAVSD repair (120 DP, 153 MSP) between 1990 and 2015.
- Analysis of early (≤30 days) and late (>30 days) outcomes, including reoperation and mortality.
- Competing risks analysis using cumulative incidence functions for survival and reoperation rates.
Main Results:
- No significant difference in reoperation or mortality rates between DP and MSP repair techniques (P = 1.0 and P = 0.9, respectively).
- Cumulative incidence of reoperation at 15 years was 17% for DP and 16% for MSP.
- Non-Down syndrome and moderate/greater left atrioventricular valve regurgitation predicted reoperation; pulmonary artery banding predicted mortality.
Conclusions:
- Both DP and MSP techniques demonstrate similar long-term event-free survival for CAVSD repair.
- Either repair technique can be safely utilized for biventricular repair of CAVSD.
- Risk factors for reoperation and mortality are identifiable, aiding in patient management.
Related Concept Videos
Long-patch Base Excision Repair
Patch Clamp
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
Fixing Double-strand Breaks
Base Excision Repair
The first step of...
Overview of DNA Repair
Chemically...
Mismatch Repair

