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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Executive function training in chronic traumatic brain injury patients: study protocol.

Daniel C Krawczyk1,2, Kihwan Han3, David Martinez3

  • 1Center for BrainHealth, The University of Texas at Dallas, 2200 Mockingbird Lane, Dallas, TX, 75235, USA. daniel.krawczyk@utdallas.edu.

Trials
|July 17, 2019
PubMed
Summary
This summary is machine-generated.

This study investigates electronic cognitive rehabilitation for chronic traumatic brain injury (TBI) survivors. Results will show if targeted digital programs improve daily executive functions and cognitive skills in TBI patients.

Keywords:
AttentionCognitive rehabilitationDaily life functionsExecutive functionsMemoryPlanningTraumatic brain injury

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Cognitive Psychology

Background:

  • Chronic traumatic brain injury (TBI) often results in persistent cognitive impairments affecting daily life.
  • Standard executive function tests may not capture deficits apparent in complex, real-world situations.
  • Electronic cognitive rehabilitation offers a novel approach to address these chronic TBI-related deficits.

Purpose of the Study:

  • To compare the efficacy of two distinct 1-month electronic cognitive rehabilitation programs for individuals with chronic TBI.
  • To assess improvements in goal-directed executive functions, including working memory, planning, and inhibitory control.
  • To evaluate the transferability of cognitive gains from a digital intervention to real-world daily functioning.

Main Methods:

  • A double-blinded clinical trial enrolling 100 participants with chronic TBI.
  • Random assignment to either an active cognitive rehabilitation program or a capped-level control program.
  • Primary outcomes measured by daily life performance tasks and functional surveys; secondary outcomes by neuropsychological tests and neuroimaging.

Main Results:

  • Anticipated primary outcomes include enhanced daily life cognitive skills and overall daily functioning.
  • Secondary outcomes are expected to show improvements in specific executive functions like working memory and attention.
  • Neuroimaging will explore changes in brain networks associated with cognitive recovery post-intervention.

Conclusions:

  • The study will determine if electronic cognitive rehabilitation improves functional and cognitive outcomes in chronic TBI.
  • It aims to identify characteristics of individuals who benefit most from such interventions.
  • Findings will elucidate the potential for cognitive training software to generalize to improvements in daily life activities.