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Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives

Jing-Bo Wang1,2, Xue Huang1,2, Fu-Rong Li3,4

  • 1Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, 1017 Dongmen Road North, Shenzhen, 518020, Guangdong, P. R. China.

Cancer Communications (London, England)
|July 17, 2019
PubMed

Insights

Lung tumors suppress dendritic cell (DC) function, hindering anti-tumor immunity. Restoring DC function offers potential for new lung cancer immunotherapies.

Area of Science:

  • Immunology
  • Oncology

Background:

  • Lung cancer is a leading cause of cancer mortality globally.
  • Dendritic cells (DCs) are crucial for anti-tumor immunity, but their function is impaired in lung cancer patients.
  • Tumor-induced immunosuppression is a significant barrier to effective anti-cancer immune responses.

Purpose of the Study:

  • To summarize recent advances in understanding lung tumor-induced immunosuppression of DCs.
  • To explore strategies for restoring DC function in lung cancer treatment.
  • To guide the development of novel immunotherapy strategies.

Main Methods:

  • Review of current research on DC function in lung cancer.
  • Analysis of mechanisms by which lung tumors suppress DC activity.
  • Evaluation of existing and potential therapeutic interventions.

Main Results:

  • Lung tumors employ various strategies to suppress DC-mediated anti-tumor immunity.
  • Impaired DC function affects T-cell initiation and development.
  • Several approaches show promise for restoring DC function.

Conclusions:

  • Understanding how lung cancer alters DC function is vital for immunotherapy design.
  • Restoring DC function is a promising avenue for clinical lung cancer treatment.
  • Further research is needed to optimize immunotherapies targeting the DC-immunosuppressive network.
Keywords:
Dendritic cellImmune regulationImmunotherapyLung cancer

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