Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

5.2K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.2K
Nerve Supply of the GI Tract01:27

Nerve Supply of the GI Tract

3.4K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
3.4K
Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

2.2K
The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
2.2K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

333
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
333
Cranial Nerves: Types Part I01:14

Cranial Nerves: Types Part I

4.9K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
4.9K
Cranial Nerves: Types Part II01:22

Cranial Nerves: Types Part II

4.7K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-Confirmed Median Nerve Pseudoconduction Block due to Anatomical Variation.

Muscle & nerve·2026
Same author

Muscle Stiffness due to Neuromuscular Hyperexcitability.

Muscle & nerve·2026
Same author

Anti-Myelin Associated Glycoprotein Neuropathy With Immune Checkpoint Inhibitor Use.

Muscle & nerve·2026
Same author

Radial Mononeuropathy: Clinical and Electrodiagnostic Characteristics in 177 Patients.

Muscle & nerve·2025
Same author

Clinical Reasoning: A 55-Year-Old Woman With Painless Hand Weakness and Atrophy.

Neurology·2024
Same author

Do Myositis-Specific Antibodies have Specific Histopathological Marks?

Annals of Indian Academy of Neurology·2023

Related Experiment Video

Updated: Jan 22, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.5K

Peripheral nerve hyperexcitability.

Bashar Katirji1

  • 1Neuromuscular Center and EMG Laboratory, Neurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, United States.

Handbook of Clinical Neurology
|July 17, 2019
PubMed
Summary
This summary is machine-generated.

Peripheral nerve hyperexcitability disorders, like Isaacs syndrome, feature abnormal muscle discharges. Early diagnosis and treatment with immunomodulatory drugs can manage these disabling conditions.

Keywords:
Cramp-fasciculation syndromeEpisodic ataxiaIsaacs syndromeMorvan syndromeMyokymiaNeuromyotoniaPeripheral nerve hyperexcitability

More Related Videos

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
09:39

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

8.6K
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

3.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.5K
Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
09:39

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Published on: July 14, 2020

8.6K
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

3.9K

Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Neuromyotonic and myokymic discharges signify peripheral nerve hyperexcitability.
  • These discharges stem from ectopic signals in motor axons.

Purpose of the Study:

  • To describe the electrophysiologic features of peripheral nerve hyperexcitability syndromes.
  • To differentiate these syndromes from other neuromuscular disorders.

Main Methods:

  • Electrophysiologic analysis of muscle discharges.
  • Clinical feature comparison.
  • Review of associated antibodies (e.g., voltage-gated potassium channel-complex antibodies).

Main Results:

  • Neuromyotonic discharges are specific to peripheral nerve hyperexcitability syndromes.
  • Myokymic discharges can be focal or generalized in various nerve disorders.
  • Isaacs and Morvan syndromes share features, often linked to specific antibodies and CNS involvement.

Conclusions:

  • Peripheral nerve hyperexcitability syndromes require distinction from conditions like stiff person syndrome.
  • Isaacs and Morvan syndromes, though severe, can respond to treatments like membrane-stabilizing drugs and immunomodulation.