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Hyperpolarized MR - What's up Doc?

Jan H Ardenkjaer-Larsen1

  • 1Technical University of Denmark, Department of Health Technology, Denmark; GE Healthcare, Denmark.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|July 17, 2019
PubMed
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Dissolution Dynamic Nuclear Polarization (dDNP) magnetic resonance imaging (MRI) has rapidly advanced to clinical trials. Building consensus is crucial for widespread adoption and realizing the full potential of this promising medical imaging technology.

Area of Science:

  • Medical Imaging
  • Nuclear Magnetic Resonance
  • Biophysics

Background:

  • Hyperpolarized MRI using dissolution Dynamic Nuclear Polarization (dDNP) emerged in 2003.
  • The technique has seen rapid clinical translation, with ongoing human studies at multiple institutions.
  • Despite its complexity, dDNP-MRI has reached a critical stage for future development.

Purpose of the Study:

  • To highlight the rapid progress of dDNP-MRI technology.
  • To emphasize the need for accelerated consensus building for widespread clinical adoption.
  • To discuss the challenges and future prospects of dDNP-MRI in clinical settings.

Main Methods:

  • Perspective paper discussing the development and clinical translation of dDNP-MRI.
  • Analysis of the collaborative efforts between academia, government, and industry.
Keywords:
Dissolution-DNPHyperpolarizationHyperpolarized MR

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  • Focus on the requirements for clinical acceptance, including strong indications and evidence.

    • Main Results:

    • dDNP-MRI has achieved rapid clinical translation since its inception.
    • Initial clinical data for dDNP-MRI is promising.
    • Significant scope for technical and clinical improvement exists.

    Conclusions:

    • Accelerated consensus building is essential for realizing the full potential of dDNP-MRI.
    • Gaining clinician acceptance requires robust evidence and clear clinical indications.
    • The future of dDNP-MRI appears bright with ongoing advancements and promising initial results.