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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

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Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
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Interdisciplinary Care: The Health Care Team-I01:21

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An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care.
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution...
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Related Experiment Video

Updated: Jan 22, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Nausea and vomiting in palliative care.

Charlotte Leach1

  • 1Royal Surrey County Hospital, Guildford, UK charlotte.leach@doctors.org.uk.

Clinical Medicine (London, England)
|July 17, 2019
PubMed
Summary

Nausea and vomiting are common in palliative care due to multiple factors like impaired gastric emptying or medications. Effective antiemetic therapy requires identifying the cause and regular reassessment for symptom control.

Area of Science:

  • Palliative Care Medicine
  • Symptom Management

Background:

  • Nausea and vomiting are prevalent symptoms in palliative care.
  • Etiology is frequently multifactorial, including impaired gastric emptying, medications, and constipation.

Purpose of the Study:

  • To highlight the importance of identifying the cause of nausea and vomiting in palliative care.
  • To emphasize the need for etiology-guided antiemetic therapy and regular reassessment.

Main Methods:

  • Clinical assessment of features suggesting the cause of nausea and vomiting.
  • Guidance of antiemetic therapy based on identified etiology.
  • Regular reassessment of symptom control.

Main Results:

  • Common causes identified: impaired gastric emptying, chemical factors (medications), and visceral factors (constipation).
Keywords:
Nauseaantiemeticpalliative carevomiting

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  • Clinical features can suggest the likely cause of nausea and vomiting.
  • Complex clinical pictures necessitate ongoing reassessment.
  • Conclusions:

    • Understanding the multifactorial etiology is crucial for managing nausea and vomiting in palliative care.
    • Tailored antiemetic strategies and frequent reassessment are essential for optimal symptom control.