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Published on: May 10, 2021
Use of Tilapia Hepcidin in Oral Cancer Therapeutics: A Proposal
Gargi S Sarode1, Krithika Gupta2, Nikunj Maniyar2
1Department of Oral Pathology and Microbiology, Dr DY Patil Dental College and Hospital, Dr DY Patil Vidyapeeth, Sant-Tukaramnagar, Pimpri, Pune, Maharashtra, India, Phone: +919823871462,
Abstract:
Tilapia hepcidin (TH), an antimicrobial peptide (AMP) derived from tilapia (Oreochromis mossambicus) forms an important component of the fish innate immune defense.1 However, the functionality of TH is not just limited to its antimicrobial actions, significant applications in cancer research remain an area to be explored. Antimicrobial peptides derived from fish and shrimp demonstrated anticancer activities in addition to their previously discovered antimicrobial action. Three hepcidin-like AMPs can be isolated from tilapia, namely TH1-5, TH2-2, and TH2-3. Of these, TH1-5 and TH2-3 have shown potent antitumor activity.2.
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