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Updated: Aug 7, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Fetal death associated with a t(1;14) in three generations
P J Barratt1, R C Juberg, M A Fritz
1Department of Obstetrics and Gynecology, Wright State University, Dayton, OH 45409.
Abstract:
Fetal death is a common phenomenon; parental chromosome study may uncover the cause of the problem and contribute to the management of the couple involved. Discovery of a translocation provides a firm basis for genetic counseling, detection of carriers, and prenatal diagnosis. We have studied a young couple with a history of 4 consecutive spontaneous abortions before cytogenetic study demonstrated the father to carry a t(1;14). The translocation was found in 2 other adults, a liveborn child, and a fetus, in a total of 3 generations.
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