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Published on: November 27, 2014
Mucosal-associated invariant T cells and disease
Amine Toubal1,2,3, Isabelle Nel1,2,3, Sophie Lotersztajn2,3,4
1Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France.
Abstract:
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.
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