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Mucosal-associated invariant T cells and disease
Amine Toubal1,2,3, Isabelle Nel1,2,3, Sophie Lotersztajn2,3,4
1Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France.
Nature Reviews. Immunology
|July 17, 2019
Summary
Mucosal-associated invariant T (MAIT) cells bridge innate and adaptive immunity, fighting infections. These unique cells also play roles in various diseases, making them promising therapeutic targets.
Area of Science:
- Immunology
- Cellular Biology
- Microbiology
Background:
- Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells.
- They connect innate and adaptive immune responses.
- MAIT cells are activated by bacterial ligands from vitamin B biosynthesis.
Purpose of the Study:
- To explore the multifaceted roles of MAIT cells.
- To understand their involvement in both protective and detrimental functions across diseases.
- To highlight MAIT cells as potential therapeutic targets.
Main Methods:
- Review of existing literature on MAIT cell function.
- Analysis of MAIT cell activation pathways.
- Examination of MAIT cell roles in various pathological conditions.
Main Results:
- MAIT cells are crucial for defense against bacterial and viral infections.
- They exhibit dual roles, contributing to both protection and pathology in autoimmune, inflammatory, and metabolic diseases.
- Their involvement spans a wide range of conditions.
Conclusions:
- MAIT cells possess significant immunomodulatory capabilities.
- Their complex functions in disease pathogenesis warrant further investigation.
- MAIT cells represent a promising avenue for novel therapeutic strategies.
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