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Susceptibility pattern of tracheal tube isolates from Intensive Care Unit of Fauji Foundation Hospital Rawalpindi

Asim Ali Shah1, Bushra Jamil2, Sarah Naseem1

  • 1Fauji Foundation Hospital, Rawalpindi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|July 17, 2019
PubMed
Abstract

Insights

Acinetobacter baumannii was the most common resistant pathogen found in intensive care unit patients. Polymyxin B showed the highest effectiveness against this bacteria.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Critical Care Medicine

Background:

  • Antimicrobial resistance is a growing threat in intensive care units (ICUs).
  • Ventilator-associated pneumonia (VAP) is a common ICU-acquired infection.
  • Identifying prevalent resistant pathogens and their susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the prevalence of resistant pathogens in an ICU.
  • To analyze the antimicrobial susceptibility patterns of isolated bacteria.
  • To guide empirical antibiotic therapy in VAP patients.

Main Methods:

  • A cross-sectional observational study was conducted in a Pakistani ICU.
  • Tracheal tubes from 80 patients with suspected VAP were collected.
  • Bacterial cultures were performed to identify pathogens and assess antibiotic susceptibility.

Main Results:

  • 113 bacterial strains were isolated from 80 patients.
  • Acinetobacter baumannii was the most prevalent (39.8%), followed by Klebsiella pneumoniae (12.3%) and MRSA (11.5%).
  • Polymyxin B demonstrated 64% sensitivity against Acinetobacter baumannii; Vancomycin and Linezolid showed 100% sensitivity against MRSA.

Conclusions:

  • Acinetobacter baumannii is the most frequent resistant pathogen in this ICU setting.
  • Polymyxin B is the most effective agent for treating Acinetobacter baumannii infections.
  • Tailoring antibiotic therapy based on local susceptibility data is essential.
Keywords:
Nosocomial infections, Tracheal tubes, Antimicrobial resistance.

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