Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midline developmental "weakness" as a consequence of determinative field properties.

M S Lubinsky1

  • 1Department of Pediatrics, University of Nebraska Medical Center, Omaha 68105.

American Journal of Medical Genetics. Supplement
|January 1, 1987
PubMed
Summary

The human midline is uniquely susceptible to developmental errors due to its position between symmetrical fields. This theoretical model explains midline malformations as primary defects in developmental patterning and tissue differentiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bearing bad news: Dealing with the mimics of denial.

Journal of genetic counseling·2013
Same author

A further report on a case of Floating-Harbor Syndrome in a mother and daughter.

Journal of clinical and experimental neuropsychology·1999
Same author

Classifying sex biased congenital anomalies.

American journal of medical genetics·1997
Same author

Decreased maternal age with hydranencephaly.

American journal of medical genetics·1997
Same author

Hypothesis: septo-optic dysplasia is a vascular disruption sequence.

American journal of medical genetics·1997
Same author

Association of prenatal vascular disruptions with decreased maternal age.

American journal of medical genetics·1997

Area of Science:

  • Developmental biology
  • Embryology
  • Human genetics

Background:

  • The human midline is a critical structure during embryonic development.
  • Midline structures are known to be vulnerable to congenital malformations.
  • Existing models do not fully explain the specific vulnerability of the midline.

Purpose of the Study:

  • To theoretically derive the midline's vulnerability to dysmorphogenesis from developmental field models.
  • To explain midline malformations as primarily determinative defects.
  • To provide evidence supporting a model where midline properties are consequences of developmental field properties.

Main Methods:

  • Theoretical modeling based on developmental field theory.
  • Analysis of positional information and symmetry in embryonic development.

Related Experiment Videos

  • Review and interpretation of existing evidence on midline malformations.

    • Main Results:

    • The midline's position on a cusp between mirror-image fields creates a "null" position for differentiation.
    • This location lacks a lateral gradient, hindering recovery from developmental disruptions.
    • Midline malformations are predicted to be primarily determinative defects with patterning and tissue abnormalities.

    Conclusions:

    • The midline's vulnerability to dysmorphogenesis is a consequence of its topological properties within developmental fields.
    • Midline malformations are explained as a result of inherent weaknesses in positional information processing.
    • This model provides a theoretical framework for understanding midline developmental defects.