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Potential Mechanisms Influencing the Inverse Relationship Between Cannabis and Nonalcoholic Fatty Liver Disease: A

Pratima Dibba1, Andrew A Li2, George Cholankeril3

  • 1Division of Gastroenterology, Women & Infants Hospital/Warren Alpert School of Medicine, Brown University, Providence, RI, USA.

Nutrition and Metabolic Insights
|July 17, 2019
PubMed

Insights

Marijuana use shows an inverse association with nonalcoholic fatty liver disease (NAFLD). This suggests potential therapeutic benefits of cannabis in managing NAFLD, warranting further investigation into underlying mechanisms.

Area of Science:

  • Hepatology
  • Endocrinology
  • Pharmacology

Background:

  • Nonalcoholic fatty liver disease (NAFLD) arises from impaired fatty acid metabolism.
  • Current NAFLD treatments focus on metabolic risk factors and lifestyle changes.
  • The endocannabinoid system is increasingly recognized for its role in NAFLD pathogenesis.

Purpose of the Study:

  • To explore the potential therapeutic role of cannabis in NAFLD.
  • To investigate the inverse association between marijuana use and NAFLD.
  • To hypothesize mechanisms linking the endocannabinoid system to NAFLD regression.

Main Methods:

  • Analysis of an existing study on marijuana use and NAFLD in US adults.
  • Review of scientific literature on the endocannabinoid system and NAFLD.
  • Integration of findings to propose mechanistic hypotheses.

Main Results:

  • A significant inverse association was observed between marijuana use and NAFLD prevalence.
  • Cannabinoid receptor modulation impacts NAFLD development and regression.
  • Exocannabinoids from cannabis may offer therapeutic benefits.

Conclusions:

  • Cannabis (marijuana) use is inversely correlated with NAFLD.
  • The endocannabinoid system presents a novel therapeutic target for NAFLD.
  • Further research is needed to elucidate the specific mechanisms behind cannabis's effect on NAFLD.
Keywords:
NAFLDNASHcannabinoidscannabisendocannabinoidendocannabinoid systemexocannabinoidmarijuananonalcoholic fatty liver diseasenonalcoholic steatohepatitis

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