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Infantile tremor syndrome: current perspectives

Rajesh Gupta1, A K Rawat2, Poonam Singh3

  • 1Department of Paediatrics, Government Medical College, Datia, MP, India.

Research and Reports in Tropical Medicine
|July 17, 2019
PubMed

Insights

Infantile Tremor Syndrome (ITS) involves tremors, anemia, and developmental issues in infants. While Vitamin B12 deficiency is suspected, management includes nutritional support and medications for tremors.

Area of Science:

  • Pediatrics
  • Neurology
  • Nutritional Science

Background:

  • Infantile Tremor Syndrome (ITS) presents with tremors, anemia, skin issues, and developmental regression.
  • The etiology of ITS remains unclear, with infectious, metabolic, and nutritional factors hypothesized.
  • Vitamin B12 deficiency is increasingly considered a potential cause, though not definitively proven.

Purpose of the Study:

  • To summarize the clinical presentation and hypothesized etiologies of Infantile Tremor Syndrome.
  • To discuss current management strategies for ITS, including nutritional supplementation and symptomatic treatment of tremors.

Main Methods:

  • Review of existing literature on Infantile Tremor Syndrome.
  • Analysis of clinical characteristics, proposed causes, and treatment approaches.

Main Results:

  • ITS is a self-limiting condition resolving within 4-6 weeks.
  • Key symptoms include coarse tremors, anemia, pigmentary skin changes, hypotonia, and developmental regression.
  • Management is often empirical, addressing potential nutritional deficiencies and managing tremors.

Conclusions:

  • The exact cause of Infantile Tremor Syndrome is not yet confirmed.
  • Vitamin B12 deficiency is a debated but developing consensus for ITS etiology.
  • Current management focuses on nutritional support (Iron, Calcium, Magnesium, Vitamin B12) and tremor control (e.g., propranolol).

Keywords:
infantile tremor syndrometremorsundernutritionvitamin B12

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