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Updated: Jan 22, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies

Claudia Sorrentino1, Antonio Cuneo1,2, Giovanni Roti1

  • 1University of Parma, Department of Medicine and Surgery, Parma, 43126, Italy.

Mediterranean Journal of Hematology and Infectious Diseases
|July 17, 2019
PubMed

Insights

The Notch pathway is crucial for cell processes and is a target in blood cancers. Targeting Notch signaling may improve outcomes for patients with leukemia and lymphoma.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The Notch pathway regulates critical cellular functions like self-renewal, proliferation, and differentiation.
  • Recurrent mutations in the Notch pathway are implicated in hematological malignancies, highlighting its significance.
  • Notch signaling contributes to therapeutic resistance and cancer stem cell maintenance in various cancers.

Purpose of the Study:

  • To review the therapeutic potential of targeting the Notch pathway in specific hematological malignancies.
  • To explore how Notch signaling influences cancer stem cells and treatment resistance.
  • To provide an overview of on-target therapeutic strategies involving the Notch pathway.

Main Methods:

  • Literature review of studies on Notch pathway in hematological malignancies.
  • Analysis of the role of Notch signaling in cancer stem cell biology.
  • Examination of Notch pathway's involvement in therapeutic resistance.

Main Results:

  • The Notch pathway is a validated target in leukemia and lymphoma due to recurrent mutations.
  • Notch signaling is a key mediator of resistance to cancer therapies.
  • Targeting Notch can impact cancer stem cells, offering potential for improved patient outcomes.

Conclusions:

  • Targeting the Notch pathway presents a promising therapeutic strategy for hematological cancers.
  • Further development of on-target therapies is warranted to improve patient outcomes.
  • This review focuses on the therapeutic potential in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and mantle cell lymphoma.
Keywords:
Chronic lymphocytic leukemiaMantle cell lymphomaNOTCH1T-cell acute lymphoblastic leukemiaTargeted therapy

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