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Lithium-induced Hyperparathyroidism and Hypercalcemia.

Srikanth Naramala1, Hussain Dalal2, Sreedhar Adapa3

  • 1Rheumatology, Adventist Medical Center, Hanford, USA.

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Summary
This summary is machine-generated.

Chronic lithium treatment for bipolar disorder can cause hypercalcemia due to hyperparathyroidism. This case study discusses the management of this rare side effect in a 66-year-old patient.

Keywords:
hypercalcemiahyperparathyroidismlithium

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a primary treatment for bipolar disorder, necessitating long-term patient management.
  • Chronic lithium use is associated with rare endocrine complications, including hyperparathyroidism.

Observation:

  • A 66-year-old female patient with a history of bipolar disorder presented with symptomatic hypercalcemia.
  • The patient was undergoing long-term treatment with lithium carbonate.

Findings:

  • Hypercalcemia was diagnosed as secondary to lithium-induced hyperparathyroidism.
  • Analysis of the case highlights the pathophysiology linking lithium therapy to parathyroid dysfunction and elevated calcium levels.

Implications:

  • Clinicians should monitor calcium levels in patients on chronic lithium therapy to detect potential hyperparathyroidism.
  • Understanding this adverse effect is crucial for managing bipolar disorder patients and preventing complications like hypercalcemia.