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Updated: Jan 22, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Severe myocardial ischemia in a patient with diabetes mellitus and left bundle branch block
Brittain Heindl1, Ami E Iskandrian2, Fadi G Hage2,3
1Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. bfheindl@uabmc.edu.
Insights
A patient with diabetes, obesity, and heart block developed cardiogenic shock awaiting surgery. This case highlights risks in patients with multivessel coronary artery disease and conduction issues.
Area of Science:
- Cardiology
- Medical Imaging
- Electrophysiology
Background:
- A 69-year-old woman with diabetes mellitus, left bundle branch block, and obesity underwent cardiac procedures.
- She developed cardiogenic shock after myocardial perfusion imaging and left heart catheterization, preceding coronary revascularization.
Observation:
- The patient had pre-existing conditions including diabetes mellitus, left bundle branch block, and obesity.
- She experienced cardiac decompensation and cardiogenic shock post-procedure but pre-revascularization.
Findings:
- Multivessel coronary artery disease poses a risk of cardiac decompensation in patients awaiting surgical intervention.
- Diabetes mellitus and left bundle branch block present imaging challenges and increase the risk of complete heart block during ischemia.
Implications:
- This case underscores the critical need for timely intervention in patients with complex coronary artery disease and conduction abnormalities.
- Careful consideration of underlying conditions is essential for safe cardiac imaging and management in high-risk patients.
- Recognizing the risk of complete heart block in ischemic events is crucial for patients with pre-existing conduction disease.
Abstract:
We present the case of a 69-year-old woman with diabetes mellitus, left bundle branch block, and obesity who develops cardiogenic shock after undergoing myocardial perfusion imaging and diagnostic left heart catheterization, but prior to coronary revascularization. This case highlights the risk of cardiac decompensation awaiting surgery in patients with multivessel coronary artery disease. It also emphasizes the subtleties involved in imaging patients with diabetes mellitus and left bundle branch block, as well as the risk of developing complete heart block in the setting of ischemia with underlying conduction disease.
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