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Myocardial fibrosis in chagas disease and molecules related to fibrosis

Ana T Chaves1, Cristiane A S Menezes2, Henrique S Costa1

  • 1Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Parasite Immunology
|July 17, 2019
PubMed

Insights

Chronic Chagas cardiomyopathy (CCC) causes significant heart disease and poor prognosis. This review explores how myocardial fibrosis in CCC links to cardiac arrhythmias, highlighting the need for noninvasive biomarkers.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Biomarkers

Background:

  • Chronic Chagas cardiomyopathy (CCC) is a leading cause of morbidity and mortality.
  • CCC presents unique characteristics compared to other cardiomyopathies, notably extensive myocardial fibrosis.
  • The disease disrupts the extracellular matrix, promoting arrhythmogenic foci and complex arrhythmias.

Purpose of the Study:

  • To investigate the association between myocardial fibrosis distribution/degree and cardiac arrhythmogenicity in Chagas cardiomyopathy.
  • To emphasize the significance of noninvasive biomarkers for quantifying myocardial fibrosis in CCC patients.

Main Methods:

  • This review synthesizes existing research on CCC pathophysiology and clinical management.
  • Focuses on studies examining myocardial fibrosis and its correlation with arrhythmias.
  • Highlights the role of noninvasive biomarkers in fibrosis assessment.

Main Results:

  • CCC is characterized by significant myocardial fibrosis, disrupting the heart's extracellular matrix.
  • This fibrosis creates an environment conducive to the development of arrhythmogenic foci.
  • CCC is highly arrhythmogenic, leading to complex arrhythmias and conduction disorders.

Conclusions:

  • A strong link likely exists between myocardial fibrosis patterns and cardiac arrhythmogenicity in CCC.
  • Noninvasive biomarkers are crucial for assessing myocardial fibrosis and managing arrhythmogenicity in Chagas patients.
  • Further research into fibrosis-arrhythmia correlation can improve CCC patient outcomes.

Keywords:
cardiac fibrosis markerscardiac remodellingchronic Chagas cardiomyopathymyocardial fibrosisventricular arrhythmic

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