Related Experiment Video
Updated: Jan 22, 2026

04:25
Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
Published on: December 15, 2023
3.8K
Human errors in manual techniques for ABO/D grouping are associated with potentially lethal outcomes
Transfusion Medicine (Oxford, England)
|July 17, 2019
Summary
Manual ABO/D grouping errors in pre-transfusion testing are significantly more common than automated methods, leading to transfusion complications. Automation and robust protocols are crucial for patient safety in blood transfusion services.
Area of Science:
- Transfusion Medicine
- Clinical Pathology
- Patient Safety
Background:
- Accurate ABO/D grouping is vital for safe pre-transfusion testing.
- Human errors in manual testing can lead to ABO/D-incompatible transfusions with severe consequences.
Purpose of the Study:
- To compare the incidence of ABO/D grouping errors between manual intervention and automation in pre-transfusion testing.
- To identify the types and causes of errors associated with manual ABO/D grouping.
Main Methods:
- Retrospective analysis of Serious Hazards of Transfusion (SHOT) reports from January 2004 to December 2016.
- Focused on ABO/D grouping errors leading to incorrect blood component transfusion.
Main Results:
- Manual intervention was implicated in 93% of ABO/D grouping errors.
- Interpretation and transcription errors were common in manual processes.
- No errors were reported with fully automated systems.
- ABO/D grouping errors have significantly decreased over the study period.
Conclusions:
- Manual ABO/D grouping processes are highly prone to human error, particularly in transcription and interpretation.
- Automation significantly reduces ABO/D grouping errors, enhancing patient safety.
- Continuous training in serological knowledge is essential for laboratory staff to complement automation.
Related Concept Videos
The ABO Blood Group
4.8K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
4.8K
Lethal Alleles
17.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
17.7K
Systematic Error: Methodological and Sampling Errors
9.9K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
9.9K
Fundamental Attribution Error
13.7K
According to some social psychologists, people tend to overemphasize internal factors as explanations—or attributions—for the behavior of other people. They tend to assume that the behavior of another person is a trait of that person, and to underestimate the power of the situation on the behavior of others. They tend to fail to recognize when the behavior of another is due to situational variables, and thus to the person’s state. This erroneous assumption is...
13.7K
Random Error
9.1K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.1K
Margin of Error
7.0K
The margin of error is also called the maximum error of an estimate. The margin of error is the maximum possible or expected difference between the observed sample parameter value and the actual population parameter value. For proportion, it is the maximum difference between the value of sample proportion obtained from the data and the true value of population proportion. As the true value of the population parameter is not known, the margin of error is calculated using the sample statistic.
7.0K

