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Updated: Jan 22, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
Published on: May 2, 2020
Tear production, intraocular pressure, and central corneal thickness in white-tailed deer (Odocoileus virginianus)
Tatiane Villar1, Ana L Pascoli2, Aislinn Klein1
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Champaign-Urbana, IL, USA.
Objective:
To evaluate the tear production, intraocular pressure, and central corneal thickness in healthy white-tailed deer (Odocoileus virginianus) and assess for seasonal variability.
Animals Studied:
Nineteen healthy fawns (3-10 days old) and 8 healthy adult white-tailed deer (164-280 days old) were studied.
Procedures:
All fawns were manually restrained for the study, while adult animals were immobilized with an intramuscular injection of combined xylazine (2.2 mg/kg), tiletamine (1 mg/kg), and zolazepam (1 mg/kg). Tear production (STT-1) was evaluated in both eyes of all fawns. Intraocular pressure (applanation and rebound tonometry) and central corneal thickness (ultrasound pachymetry) were determined in both eyes of all fawns and adult deer.
Results:
Mean ± SD tear production in fawns was 12.32 ± 4.46 mm/min. Mean ± SD IOP values in the fawns were 16.21 ± 4.97 mm Hg (TonoPen® ) and 14.05 ± 5.03 mm Hg (TonoVet® ). In adult deer, mean ± SD IOP values were 15.57 ± 2.88 mm Hg with TonoPen® and 12.87 ± 2.57 with TonoVet® , and TonoPen® significantly overestimated the IOP, compared to TonoVet® (P < 0.005). The IOP was not significantly different between young and adult animals (P = 0.22). A significant difference (P < 0.005) in CCT values was observed between fawns (528.42 ± 27.65 μm) and adult deer (747.55 ± 41.60 μm).
Conclusions:
This study reports normal values of tear production in healthy fawns, and intraocular pressure and central corneal thickness in healthy young and adult white-tailed deer.
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