A Study on the Association of Psoriasis with Metabolic Disorders

Psoriasis is a chronic inflammatory and hyper-proliferative skin disorder which is chronically relapsing with high morbidity and impaired quality of life, characterized by erythematous scaly patches affecting skin, joints and nails. It is a disorder of immune system involving genetic, immunologic and environtmental factors. Metabolic syndrome (also known as metabolic syndrome X) is a grouping of interrelated medical traits that, when present, indicate an increased risk of developing noninsulin-dependent diabetes mellitus and/or cardiovascular disease.

An attempt to find out the association between psoriasis and metabolic disorders by measuring height, weight, body mass index, hip circumference,waist circumference and its ratio, blood pressure and severity of psoriasis patients by PASI (Baseline psoriasis and severity index) score. Further, to investigate each and every patient with complete blood count, fasting and post-prandial blood glucose levels, thyroid profile,lipid profile.

It is a hospital based Case-control study conducted at Department of Dermatology, Venereology and Leprology at Dr.D.Y. Patil Hopsital Nerul, Navi Mumbai for a duration of October 2015 -October 2016 with sample size of 100 patients of Psoriasis along with 100 patients of controls. Informed consent was taken from patients to satisfy the inclusion criteria with patients clinically diagnosed as psoriasis, above 18 years and those who participated in the study not having psoriasis as the controls with no exclusion criteria. An information sheet was given to all the participating patients.

Ethical committee approval, informed Consent were taken from the patients. Severity of psoriasis by PASI score (Baseline psoriasis and severity index) along with height, weight, waist circumference: hip circumference, body mass index were measured. Investigations carried out in all patients were CBC, FBS, PLBS, Thyroid profile, Lipid profile and results were statistically analyzed at the end of study. RESULTS: Out of 200 patients, The observation was in accordance of psoriasis being associated with metabolic syndrome in 71% cases as compared to 37% controls.

The blood pressure, sr. triglycerides, sr. high density lipids, fasting blood sugar were significant in cases as compared to controls satisfying the criteria of Adult Panel Treatment III (ATP III) of Metabolic Disorders.