An Expert Review and Recommendations on the Rational Use of Proton Pump Inhibitors: Indian Perspective
Shobna Bhatia1, Akash Shukla2, David Johnson3
1Professor and Head, Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.
The Journal of the Association of Physicians of India
|July 17, 2019
Summary
Proton pump inhibitors (PPIs) are essential for acid peptic diseases but often misused. This review offers expert recommendations for appropriate PPI use in India to improve patient outcomes and reduce healthcare costs.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) are primary treatments for acid peptic diseases (APDs).
- Irrational prescription of PPIs is common, leading to suboptimal outcomes and increased healthcare costs.
- Rational PPI use is crucial for optimizing treatment efficacy and safety.
Purpose of the Study:
- To review the efficacy and safety of PPIs.
- To provide recommendations for the rational use of PPIs from an Indian perspective.
Main Methods:
- An expert group of 12 healthcare professionals (including gastroenterologists and a clinical pharmacologist) was formed.
- The group reviewed articles published between 2000 and 2017 on PPI efficacy and safety.
- Expert opinions and clinical experiences were synthesized to formulate recommendations.
Main Results:
- PPIs are recommended for a minimum of 12 weeks for healing esophagitis in GERD patients.
- Long-term PPI use is advised for patients with Barrett's esophagus.
- PPIs are recommended for NSAID users at high risk of ulcer bleeding.
Conclusions:
- This expert review provides key recommendations to minimize irrational PPI use.
- Recommendations aim to assist clinical decision-making for various acid-related conditions.
- Best practice guidelines support, but do not mandate, PPI prescription decisions.
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