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Angioedema Masqueraders.

Jie Shen Fok1,2, Constance H Katelaris3,4

  • 1Department of Respiratory Medicine, Box Hill Hospital, Melbourne, Victoria, Australia.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|July 17, 2019
PubMed
Summary
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Many patients referred for angioedema are misdiagnosed. This review explores various conditions that mimic angioedema across different body parts, aiding accurate diagnosis for allergy and immunology specialists.

Area of Science:

  • Allergy and Immunology
  • Dermatology
  • Emergency Medicine

Background:

  • Angioedema is a frequent reason for specialist referral, but misdiagnosis is common.
  • Conditions mimicking angioedema can lead to delayed or incorrect treatment.
  • A low index of clinical suspicion or unfamiliarity with similar conditions contributes to diagnostic errors.

Purpose of the Study:

  • To present a comprehensive list of differential diagnoses for angioedema.
  • To categorize mimickers of angioedema by affected body part.
  • To improve diagnostic accuracy for clinicians encountering suspected angioedema.

Main Methods:

  • Literature review of conditions presenting as angioedema.
  • Categorization of differential diagnoses based on anatomical location (lips, limbs, face, etc.).
Keywords:
allergic contact dermatitisangioedemaangioedema masqueradersangioedema mimicscheilitis granulomatosaclinical immunology

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  • Clinical presentation analysis of masquerading conditions.
  • Main Results:

    • Numerous conditions can clinically resemble angioedema.
    • Mimicking conditions are identified in various body regions, including the face, genitalia, and airway.
    • Accurate identification requires awareness of these diverse presentations.

    Conclusions:

    • Recognizing conditions that mimic angioedema is crucial for correct diagnosis and management.
    • A systematic, body-part-based approach aids in differentiating true angioedema from its mimics.
    • Enhanced clinical awareness can prevent misdiagnosis and improve patient outcomes in allergy and immunology.