Related Experiment Video

Updated: Jan 22, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K

Tumor-Targeting NIRF NanoGUMBOS with Cyclodextrin-Enhanced Chemo/Photothermal Antitumor Activities

Mi Chen, Rocío L Pérez, Pu Du

    ACS Applied Materials & Interfaces
    |July 17, 2019
    PubMed

    Insights

    Researchers developed novel nanomaterials (nanoGUMBOS) from the IR780 dye for enhanced cancer theranostics. These nanoGUMBOS show improved stability, selective cancer cell toxicity, and effective in vivo tumor treatment via combined chemo/photothermal therapy.

    Area of Science:

    • Biomaterials Science
    • Nanotechnology
    • Cancer Therapeutics

    Background:

    • Near-infrared fluorescent (NIRF) dye IR780 shows theranostic potential but suffers from poor photostability and non-selective toxicity.
    • Limitations hinder the clinical translation of IR780 for cancer imaging and therapy.

    Purpose of the Study:

    • To develop enhanced nanomaterials based on IR780 for improved chemo/photothermal therapy and theranostics.
    • To overcome the limitations of IR780 by creating cyclodextrin-complexed GUMBOS (CD-based nanoGUMBOS).

    Main Methods:

    • Synthesis of GUMBOS via counter-anion exchange with IR780.
    • Formation of CD-based nanoGUMBOS through complexation.
    • In vitro cytotoxicity assays and NIR laser irradiation studies.
    • In vivo near-infrared fluorescence (NIRF) imaging and therapeutic efficacy evaluation.

    Main Results:

    • CD-based nanoGUMBOS exhibited enhanced aqueous stability, photostability, and photothermal effects compared to IR780.
    • In vitro studies showed selective toxicity of CD-based nanoGUMBOS toward cancer cells, with synergistic effects upon NIR irradiation.
    • In vivo NIRF imaging confirmed selective tumor accumulation and targeting.
    • Therapeutic studies demonstrated significant chemo/photothermal antitumor effects.

    Conclusions:

    • Conversion of IR780 into CD-based nanoGUMBOS offers a promising strategy for improved cancer theranostics.
    • The developed nanoGUMBOS provide enhanced stability, targeted delivery, and synergistic therapeutic efficacy.
    • This approach represents a significant advancement in developing effective theranostic agents for cancer treatment.
    Keywords:
    IR780NIRFchemo/photothermal applicationscyclodextrinnanoGUMBOStheranostic

    More Related Videos

    Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution06:42

    Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

    Published on: May 9, 2025

    1.1K
    One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles09:51

    One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

    Published on: September 17, 2013

    11.2K

    Related Concept Videos

    Self-Evaluation: Self-Enhancement and Self-Verification03:00

    Self-Evaluation: Self-Enhancement and Self-Verification

    Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
    5.7K
    Bioavailability Enhancement: Drug Solubility Enhancement01:16

    Bioavailability Enhancement: Drug Solubility Enhancement

    Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
    229
    Bioavailability Enhancement: Drug Permeability Enhancement01:27

    Bioavailability Enhancement: Drug Permeability Enhancement

    Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
    194
    Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

    Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

    Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
    203
    MOSFET: Enhancement Mode01:22

    MOSFET: Enhancement Mode

    Enhancement-mode MOSFETs are pivotal components in electronics, distinguished by their capacity to act as highly efficient switches. They are part of the larger family of metal-oxide Semiconductor Field-Effect Transistors (MOSFETs). They are available in two types: p-channel and n-channel, each tailored to specific polarity operations.
    In their basic form, enhancement-mode MOSFETs are typically non-conductive when the gate-source voltage (Vgs) is zero. This default 'off' state means no...
    801
    Enhanced Elimination of Poison01:26

    Enhanced Elimination of Poison

    Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
    Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
    Renal excretion is the...
    877