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Association between sensitization and allergic diseases in 7-years-old Korean children

Eun Lee1, Dong In Suh2, So-Yeon Lee3

  • 1Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Asian Pacific Journal of Allergy and Immunology
|July 17, 2019
PubMed

Insights

Childhood sensitization patterns, including allergen type and degree, are linked to allergic diseases like asthma and allergic rhinitis. Understanding these patterns aids in identifying disease causes and varied presentations.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Clinical Medicine

Background:

  • Allergic diseases in children are often exacerbated by sensitization.
  • Sensitization patterns influence disease severity and prognosis.

Purpose of the Study:

  • To investigate the relationship between specific sensitization patterns and allergic diseases in children.
  • To characterize how allergen type, number, and degree of sensitization correlate with allergic conditions.

Main Methods:

  • A cohort of 548 children from the Panel Study of Korean Children (PSKC) was analyzed.
  • Skin prick tests (SPTs) for 18 allergens, blood tests, and methacholine challenge tests were conducted at age 7.
  • The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was administered.

Main Results:

  • The overall sensitization rate was 46.4%.
  • Indoor allergen sensitization correlated with asthma, allergic rhinitis (AR), and atopic dermatitis (AD) symptoms.
  • Outdoor allergen sensitization was linked to AR diagnosis. The number and degree of sensitization influenced AR and asthma diagnoses and symptoms.

Conclusions:

  • Sensitization patterns provide valuable insights into the association between sensitization and allergic diseases.
  • Analyzing allergen type, number, and degree helps identify underlying pathophysiologies and diverse phenotypes of pediatric allergic diseases.
Abstract

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