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Updated: Jan 22, 2026
12:58
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
Published on: September 12, 2019
10.2K
Localized surface curvature artifacts in tip-enhanced nanospectroscopy imaging.
E Sheremet1, L Kim1, D Stepanichsheva1
1Tomsk Polytechnic University, 30 Lenin Ave, 634050 Tomsk, Russia.
Ultramicroscopy
|July 17, 2019
Summary
Tip-enhanced Raman spectroscopy (TERS) imaging can be affected by artifacts. This study analyzes tip-sample coupling effects and substrate curvature in gap-mode TERS for more reliable nanoscale chemical analysis.
Area of Science:
- Nanotechnology
- Spectroscopy
- Materials Science
Background:
- Tip-enhanced Raman spectroscopy (TERS) offers nanoscale chemical analysis beyond the diffraction limit.
- Gap-mode TERS enhances sensitivity using metallic substrates.
- Tip-sample coupling can introduce imaging artifacts in TERS.
Purpose of the Study:
- To provide a generalized view of imaging artifacts in TERS and near-field imaging.
- To investigate the role of tip-sample coupling and substrate geometry in gap-mode TERS.
- To understand the impact of nanoscale curvature on TERS imaging.
Main Methods:
- Experimental investigation of various substrates.
- Numerical simulations to complement experimental data.
- Analogy drawn with atomic force microscopy artifacts.
Main Results:
- Tip convolution effects can broaden observed dimensions in 3D nanostructures due to sample curvature.
- Substrate curvature significantly impacts gap-mode TERS imaging, contrary to idealized flat substrate models.
- Geometrical effects of substrates were evidenced, clarifying their role in TERS.
Conclusions:
- This work offers a comprehensive analysis of artifacts in gap-mode TERS imaging.
- Understanding tip- and substrate-related artifacts is crucial for reliable near-field optical nanospectroscopy.
- The study enhances the understanding and reliability of nanoscale chemical analysis using TERS.
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