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Updated: Jan 22, 2026
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A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
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Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma
Wei Cheng1, Bin Zhang1, Mulager Zikeliyar1
1Department of Hematologic and Oncology, the Center Hospital of Karamay City, Karamay 834000, Xinjiang, China.
Annals of Diagnostic Pathology
|July 17, 2019
Summary
Mortalin is overexpressed in hepatocellular carcinoma (HCC) and its elevated levels predict poor prognosis. This study confirms Mortalin as an independent prognostic factor for HCC survival.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Mortalin's association with survival in various cancers is known.
- Its prognostic role in hepatocellular carcinoma (HCC) remains underexplored.
Purpose of the Study:
- To investigate the prognostic significance of Mortalin expression in HCC.
- To correlate Mortalin levels with clinicopathological features and patient survival.
Main Methods:
- Immunohistochemistry was used to assess Mortalin expression in 90 HCC tissues and paired normal controls.
- Statistical analyses, including Kaplan-Meier curves and Cox regression, were performed.
- Clinicopathological variables such as tumor size, differentiation, and metastasis were analyzed.
Main Results:
- Mortalin was significantly overexpressed in HCC tissues compared to normal controls.
- Elevated Mortalin expression correlated with vascular invasion, advanced clinical stage, and intrahepatic metastasis.
- High Mortalin levels were associated with shorter overall survival and disease-free survival.
Conclusions:
- Mortalin is a valuable independent prognostic biomarker for hepatocellular carcinoma.
- Its expression levels can predict patient outcomes and inform treatment strategies.
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