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Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men

Yuji Takaeko1, Shogo Matsui1, Masato Kajikawa2

  • 1Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Journal of Clinical Lipidology
|July 18, 2019
PubMed

Insights

Extremely high levels of high-density lipoprotein cholesterol (HDL-C) in men are linked to reduced endothelial function, indicating HDL-C may be a double-edged sword for atherosclerosis risk.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Endothelial Function

Background:

  • The role of high-density lipoprotein cholesterol (HDL-C) in atherosclerosis remains unclear, with potential for both protective and detrimental effects.
  • Understanding the relationship between HDL-C levels and vascular health is crucial for assessing cardiovascular risk.

Purpose of the Study:

  • To investigate the association between varying levels of HDL-C and endothelial function in a large cohort of men.
  • To determine if extremely high HDL-C is associated with impaired endothelial function.

Main Methods:

  • Cross-sectional study of 5842 men aged 18-92 years without lipid-lowering therapy.
  • Measurement of flow-mediated vasodilation (FMD) as an indicator of endothelial function.
  • Categorization of participants into four HDL-C groups: low, moderate, high, and extremely high.

Main Results:

  • Flow-mediated vasodilation (FMD) was significantly lower in the low HDL-C and extremely high HDL-C groups compared to the high HDL-C group.
  • Extremely high HDL-C levels (≥80 mg/dL) were independently associated with the lowest quartile of FMD (OR: 1.39, 95% CI: 1.09-1.77).
  • No significant difference in FMD was observed between the low and extremely high HDL-C groups.

Conclusions:

  • Extremely high HDL-C levels in men are associated with a significant reduction in endothelial function, as measured by FMD.
  • These findings suggest that HDL-C may act as a double-edged sword in the context of atherosclerosis.
  • Further research is needed to elucidate the mechanisms behind the impaired endothelial function in individuals with extremely high HDL-C.
Abstract

Keywords:
AtherosclerosisEndothelial functionFlow-mediated vasodilationHigh-density lipoprotein cholesterolMen

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