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Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation

Ilige Youssef1,2, Jean-Marc Ricort3,2,4

  • 1Centre National de la Recherche Scientifique, CNRS UMR_8113, Laboratoire de Biologie et Pharmacologie Appliquée, Cachan, France.

Molecular Cancer Research : MCR
|July 18, 2019
PubMed

Insights

Protein kinase D1 (PKD1) impacts tumor progression. This review examines PKD1

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein kinase D1 (PKD1) is a serine/threonine kinase involved in tumor progression mechanisms like motility, invasion, and apoptosis.
  • PKD1 expression varies during tumorigenesis, and its role in cell proliferation is context-dependent and not fully understood.
  • Understanding PKD1's proliferative effects is crucial for its potential as a therapeutic target.

Purpose of the Study:

  • To review and discuss current research on the role of PKD1 in the proliferation of cancerous and normal cells.
  • To elucidate whether PKD1 promotes or inhibits proliferation under specific conditions.
  • To assess PKD1 as a potential therapeutic target in cancer.

Main Methods:

  • Literature review of studies investigating PKD1's role in cell proliferation.
  • Analysis of experimental data on PKD1 expression and function in various cancer types and normal cells.
  • Synthesis of findings to determine the context-dependent effects of PKD1.

Main Results:

  • PKD1's role in proliferation is complex and varies significantly depending on the cellular context and cancer type.
  • Evidence suggests both pro- and anti-proliferative roles for PKD1 in different tumor models.
  • PKD1 signaling pathways are implicated in diverse cellular processes relevant to cancer.

Conclusions:

  • Deciphering the precise role of PKD1 in proliferation is critical for developing targeted cancer therapies.
  • PKD1's context-dependent function necessitates tailored therapeutic strategies.
  • Further research is needed to fully understand and exploit PKD1's therapeutic potential in oncology.

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