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BLU-667 Controls RET-Altered Thyroid Cancers

    Cancer Discovery
    |July 18, 2019
    PubMed

    Insights

    The experimental RET inhibitor BLU-667 shows promise for thyroid cancer. This drug is safe and effective in patients with RET-altered medullary and papillary thyroid cancers.

    Area of Science:

    • Oncology
    • Molecular Biology

    Background:

    • The study investigates the efficacy of BLU-667, an experimental RET inhibitor, in treating RET-altered thyroid cancers.
    • Findings were presented at the 2019 American Society of Clinical Oncology Annual Meeting.

    Discussion:

    • BLU-667 demonstrated significant response rates in patients with advanced RET-mutated medullary thyroid cancer (56%).
    • The drug also showed effectiveness in patients with papillary thyroid cancer, with five out of six achieving a response.

    Key Insights:

    • The ARROW trial (Phase II) indicates BLU-667 is a safe and effective treatment option.
    • Observed side effects were generally mild, suggesting a favorable safety profile.

    Outlook:

    • BLU-667 represents a potential new therapeutic strategy for RET-driven thyroid malignancies.
    • Further research and clinical trials may solidify its role in personalized cancer therapy.

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