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Related Experiment Videos

Thyroxine surge in metamorphosing flounder larvae.

S Miwa1, M Tagawa, Y Inui

  • 1Inland Station, National Research Institute of Aquaculture, Mie, Japan.

General and Comparative Endocrinology
|April 1, 1988
PubMed
Summary
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Thyroid hormone thyroxine (T4) surges during flounder metamorphosis, driving fin ray resorption and eye translocation. This study reveals thyroid hormone

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Ichthyology

Background:

  • Metamorphosis in fish, particularly flounder (Paralichthys olivaceus), involves significant physiological and morphological changes.
  • Thyroid hormones are known regulators of vertebrate metamorphosis, but their precise roles and temporal dynamics in fish require further elucidation.

Purpose of the Study:

  • To quantify tissue thyroxine (T4) concentrations during flounder metamorphosis.
  • To correlate T4 levels with specific metamorphic events like fin ray growth/resorption and eye translocation.
  • To investigate the role of T4 in pre- and post-metamorphic development.

Main Methods:

  • Radioimmunoassay (RIA) for T4 quantification in fish eggs and larvae.
  • Quantitative extraction of hormones from biological samples.

Related Experiment Videos

  • Hormonal manipulation experiment using T4 and thiourea in early life stages.

    • Main Results:

    • T4 levels were undetectable until metamorphic climax, then sharply increased, coinciding with fin ray resorption and eye translocation.
    • Peak T4 levels were maintained through climax, declining in post-metamorphic juveniles.
    • Hormonal manipulation suggested negative feedback regulation of the pituitary-thyroid axis.

    Conclusions:

    • Metamorphic climax in flounder is induced by a surge in thyroid hormone (T4).
    • Thyroid hormone plays a crucial role in regulating key metamorphic events.
    • Thyroid hormone involvement extends to developmental stages before and after metamorphosis.