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The Altered Somatic Brain Network in State Anxiety.

Xianrui Li¹, Meng Zhang^1,2, Kun Li²

¹School of Psychology, Xinxiang Medical University, Xinxiang, China.

Frontiers in Psychiatry

|July 18, 2019

Summary

High anxiety levels correlate with increased spontaneous brain activity in the body

Keywords:

postcentral gyrus resting-state functional magnetic resonance imaging somatic marker hypothesis somatosensory cortex state anxiety

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Area of Science:

Neuroscience
Psychology
Medical Imaging

Background:

Anxiety is linked to emotional and cognitive biases.
Somatic arousal in anxiety and its neural basis are under-researched.
Spontaneous brain activity and functional connectivity in anxiety require further investigation.

Purpose of the Study:

To examine the relationship between state anxiety and spontaneous brain activity in the somatosensory cortex.
To explore functional connections of the somatosensory cortex in relation to state anxiety.
To investigate anxiety's impact on the body-loop in healthy individuals.

Main Methods:

Utilized functional magnetic resonance imaging (fMRI) to measure spontaneous brain activity.
Analyzed amplitude of low-frequency fluctuations (ALFFs) in brain regions.
Investigated functional connectivity between the somatosensory cortex and other brain areas.

Main Results:

State anxiety positively correlated with ALFFs in the right postcentral gyrus (somatosensory cortex) and right precentral gyrus (somatic motor cortex).
State anxiety positively correlated with connectivity between the postcentral gyrus and the left cerebellum.
State anxiety negatively correlated with connectivity between the postcentral gyrus and the left inferior frontal cortex and left medial superior frontal cortex.

Conclusions:

Somatic brain regions are significantly associated with state anxiety in healthy individuals.
Anxiety impacts the functional connectivity of the somatosensory cortex.
Findings offer a new perspective on the neural underpinnings of anxiety, emphasizing the body-loop.