Related Experiment Video
Updated: Jan 22, 2026

Isolated Pancreatic Islet Treatment and Apoptosis Measurement
Published on: May 2, 2025
Secreted klotho from exosomes alleviates inflammation and apoptosis in acute pancreatitis
Na Wang1, Jiali Ma1, Yuehan Ren1
1Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine 1111 Xianxia Road, Shanghai 200336, China.
Abstract:
Acute pancreatitis is a potentially lethal disorder characterized by inflammation and apoptosis of parenchymal cells. Repeated acute pancreatitis results in chronic pancreatitis and is the major risk factor for pancreatic cancer. Current therapeutic approaches focus on anti-inflammatory and anti-apoptotic. However, the molecular mechanisms that lead to apoptosis and pathogenesis in acute pancreatitis remain unclear. Here, in the current study, we developed a novel approach that using exosomes from mesenchymal stem cells that overexpress Klotho reversed apoptosis, nuclear factor-kB activation in caerulein-stimulated AR42J cells. Klotho attenuated the severity of pancreatic inflammation after caerulein treatment. In conclusion, our results provide evidence that Klotho is a potential therapeutic target for clinical interventions towards acute pancreatitis.
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