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Related Experiment Video

Updated: Jan 22, 2026

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Artemether improves type 1 diabetic kidney disease by regulating mitochondrial function.

Yao Wang1, Pengxun Han1, Menghua Wang1

  • 1Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China.

American Journal of Translational Research
|July 18, 2019
PubMed
Summary
This summary is machine-generated.

Artemether, an antimalarial drug, shows promise in protecting kidneys from type 1 diabetes complications. It improves mitochondrial function and reduces kidney damage in diabetic mice, offering potential therapeutic benefits for diabetic kidney disease.

Keywords:
Artemetherdiabetic kidney diseasemitochondrial function

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Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic kidney disease (DKD) is a major complication of type 1 diabetes mellitus (T1DM).
  • Mitochondrial dysfunction and reactive oxygen species contribute significantly to DKD progression.
  • The antimalarial drug artemether has demonstrated antidiabetic properties.

Purpose of the Study:

  • To investigate the renoprotective effects of artemether in a mouse model of T1DM.
  • To explore the impact of artemether on mitochondrial function and redox balance in the context of DKD.

Main Methods:

  • Streptozotocin-induced diabetes in mice was used to model T1DM.
  • Mice were treated with artemether to assess its effects on renal and metabolic parameters.
  • Kidney function, hypertrophy, islet hormone levels, and mitochondrial function were evaluated.

Main Results:

  • Artemether treatment attenuated renal hypertrophy and reduced urinary albumin and tubular injury biomarkers.
  • Hyperglycemia was prevented, serum insulin levels increased, and islet hormone ratios were restored with artemether.
  • Artemether improved mitochondrial function and redox balance in the kidneys.

Conclusions:

  • Artemether demonstrates significant renal protection in a T1DM mouse model.
  • Improved mitochondrial function is a likely mechanism underlying artemether's renoprotective effects in DKD.
  • Artemether holds potential as a therapeutic agent for managing T1DM-related kidney disease.