Related Experiment Video

Updated: Jan 22, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.6K

Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India

Ram Prabhoo1, Ram Chaddha2, Rajagopalan Iyer3

  • 1Department of Orthopedic Surgery, Mukund Hospital Mumbai, Maharashtra.

Orthopedic Reviews
|July 18, 2019
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) poses a growing challenge in bone and joint infections (BJI). New antibiotics are crucial to overcome treatment limitations and combat resistant strains effectively.

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Pharmacology

Background:

  • Staphylococcus aureus is a primary cause of bone and joint infections (BJI).
  • The rising prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) in India complicates BJI treatment.
  • Existing anti-MRSA drugs face challenges including reduced efficacy, safety concerns, and biofilm formation on prosthetics.

Purpose of the Study:

  • To review the current landscape of MRSA in BJIs.
  • To discuss the limitations of existing antibiotic regimens for MRSA-induced BJIs.
  • To highlight the urgent need for novel antibiotic development against MRSA.

Main Methods:

  • Literature review focusing on MRSA in bone and joint infections.
  • Analysis of current antibiotic treatment strategies and their associated challenges.
  • Discussion on the implications of antibiotic resistance and biofilm formation.

Main Results:

  • MRSA is a significant and increasing pathogen in BJIs, particularly in India.
  • Current anti-MRSA agents have limitations in efficacy, safety, and overcoming drug resistance.
  • Biofilm formation on prosthetic devices exacerbates treatment complexity.

Conclusions:

  • Effective management of MRSA-related BJIs requires addressing limitations of current therapies.
  • Development of new antibiotics with improved penetration and activity against resistant strains is essential.
  • Novel therapeutic strategies are needed to combat challenging MRSA infections in bone and joint settings.
Keywords:
BiofilmsBone and joint infectionMethicillin resistant S.aureusNewer anti-MRSA agents

More Related Videos

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus08:32

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

1.2K
Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

12.3K

Related Concept Videos

Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
6.5K
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.6K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
3.9K
Joints01:26

Joints

Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.5K
Introduction to Joints00:58

Introduction to Joints

The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
4.7K
Ankle Joint01:10

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
2.8K