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Haemostasis during treatment with ciprofloxacin
M Ziemen1, P M Shah, K Breddin
1Center of Internal Medicine, J. W. Goethe University, Frankfurt am Main.
Infection
|January 1, 1988
Summary
Ciprofloxacin, a new quinolone antibiotic, showed no impact on platelet function in healthy volunteers. A minor decrease in antithrombin III activity was noted in some participants during therapy.
Area of Science:
- Pharmacology
- Microbiology
- Hematology
Background:
- Ciprofloxacin is a novel quinolone antibiotic.
- It exhibits broad-spectrum activity against Gram-negative aerobic bacteria and Gram-positive cocci.
- Its potential effects on hemostasis require investigation.
Purpose of the Study:
- To investigate the effects of ciprofloxacin on hemostasis in healthy volunteers.
- To assess the impact of ciprofloxacin on platelet function and plasma coagulation parameters.
Main Methods:
- 11 healthy volunteers participated in the study.
- Hemostasis parameters, including platelet function and plasma coagulation, were measured.
- Antithrombin III activity was specifically monitored.
Main Results:
- No significant influence of ciprofloxacin on platelet function was observed.
- A slight reduction in antithrombin III activity was noted in some subjects at the conclusion of therapy.
- No other alterations in plasma coagulation parameters were detected.
Conclusions:
- Ciprofloxacin does not appear to significantly affect platelet function or most plasma coagulation parameters.
- A potential minor impact on antithrombin III activity warrants consideration during ciprofloxacin therapy.