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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia

Xintong Jiang1, Feilong Wang2, Yajuan Wang1

  • 1Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

JACC. Basic to Translational Science
|July 18, 2019
PubMed

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Keywords:
ASC, apoptosis-associated speck-like protein containing a CARDATP, adenosine 5′-triphosphate disodium salt hydrateBiKE, Biobank of Karolinska Carotid EndarterectomiesCT, Computerized tomographic scanningIL, interleukinLDL, low-density lipoproteinLPS, lipopolysaccharideNLRC, nucleotide-binding oligomerization domain, leucine-rich repeat and CARD domain–containing proteinNLRP, nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain–containing proteinPBS, phosphate-buffered salineatherosclerosishypercholesterolemiainflammasomeinflammationinterleukin-1mRNA, messenger ribonucleic acid