Related Experiment Video
Updated: Jan 22, 2026

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
Unexpected Finding on Mammography and MRI due to Accumulation of Iron Oxide Particles Used for Sentinel Lymph Node
Gözde Arslan1, Cem Yılmaz2, Levent Çelik3
1Department of Radiology, Maltepe University, İstanbul, Turkey.
Abstract:
We present a case with imaging artefacts on mammography and Magnetic Resonance Imaging (MRI) caused by iron oxide particles. After being diagnosed with the medullary cancer of the breast, the female patient had a breast conserving surgery on right breast. Iron oxide particles were used for the detection of the sentinel lymph node during operation. On follow ups, a de novo density on mammography, which was initially thought to be a new tumour, was found. MR images proved that the lesion is an artefact caused by iron oxide accumulation. Our aim in this case study is to underline and discuss the imaging artefacts caused by these particles and raise awareness.
Insights
Iron oxide particles used in breast cancer surgery can cause imaging artifacts on mammography and MRI. This case highlights the importance of recognizing these artifacts to avoid misdiagnosis of new tumors.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Sentinel lymph node biopsy is crucial in breast cancer staging.
- Iron oxide particles aid in sentinel lymph node detection during surgery.
- Accurate interpretation of follow-up imaging is vital for patient management.
Observation:
- A patient treated for breast cancer developed a new density on mammography post-surgery.
- This density was initially suspected to be a recurrent tumor.
- Magnetic Resonance Imaging (MRI) revealed the density was an artifact.
Findings:
- The observed imaging artifact was caused by the accumulation of iron oxide particles used during sentinel lymph node detection.
- Mammography and MRI can both be affected by these iron oxide-based contrast agents.
- Distinguishing artifacts from actual pathology is critical for correct diagnosis.
Implications:
- Awareness of iron oxide particle imaging artifacts is essential for radiologists and surgeons.
- Misinterpretation can lead to unnecessary anxiety and further invasive procedures.
- Understanding these artifacts improves diagnostic accuracy in breast cancer follow-up.
Related Concept Videos
Detailed Structure and Function of Lymph Nodes
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Oxidation Numbers
Finding the Center of Gravity
Respiratory System Abnormal Finding I: Inspection and Percussion
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Cardiovascular System Abnormal Findings I: Inspection and Palpation
Abnormal findings observed during an inspection
Finding Electric Potential From Electric Field

