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Gene expression in stress urinary incontinence: a systematic review
Ilaha Isali1, Amr Mahran1,2, Ahmad O Khalifa1,3
1Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
International Urogynecology Journal
|July 18, 2019
Summary
Genetic factors contribute to stress urinary incontinence (SUI). This study identified 13 differentially expressed genes in SUI patients, offering potential therapeutic targets and biomarkers for future research.
Area of Science:
- Genetics and Molecular Biology
- Urology
- Biochemistry
Background:
- Genetic factors are recognized contributors to the development of stress urinary incontinence (SUI).
- Understanding the genetic underpinnings of SUI is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the genetic pathogenesis of SUI by analyzing differential gene expression in patients.
- To identify potential novel therapeutic targets and leads for SUI management.
Main Methods:
- A systematic literature search was performed to identify studies on genetics and SUI.
- Gene networking and functional analyses were conducted using GeneMANIA software on differentially expressed genes.
Main Results:
- Four studies identified 13 differentially expressed genes in SUI patients.
- Eleven genes were overexpressed, including SKALP, COL17A1, PKP1, KRT16, DCN, BGN, BICD2, GRB2, STAT3, APOE, and GOSR1.
- Two genes, FMOD and GBA, were underexpressed. These genes are involved in cytoskeleton and extracellular matrix organization.
Conclusions:
- Multiple genes play a role in SUI pathogenesis.
- Further whole-genome studies are needed to elucidate genetic connections.
- This research provides a foundation for developing novel SUI therapies and biomarkers.
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