PEEP titration in moderate to severe ARDS: plateau versus transpulmonary pressure

Although lung protection with low tidal volume and limited plateau pressure (P_plat) improves survival in acute respiratory distress syndrome patients (ARDS), the best way to set positive end-expiratory pressure (PEEP) is still debated.

This study aimed to compare two strategies using individual PEEP based on a maximum P_plat (28-30 cmH₂O, the Express group) or on keeping end-expiratory transpulmonary pressure positive (0-5 cmH₂O, P_Lexpi group). We estimated alveolar recruitment (Vrec), end-expiratory lung volume and alveolar distension based on elastance-related end-inspiratory transpulmonary pressure (P_L,EL).

Nineteen patients with moderate to severe ARDS (PaO₂/FiO₂ < 150 mmHg) were included with a baseline PEEP of 7.0 ± 1.8 cmH₂O and a PaO₂/FiO₂ of 91.2 ± 31.2 mmHg. PEEP and oxygenation increased significantly from baseline with both protocols; PEEP Express group was 14.2 ± 3.6 cmH₂O versus 16.7 ± 5.9 cmH₂O in P_Lexpi group. No patient had the same PEEP with the two protocols. Vrec was higher with the latter protocol (299 [0 to 875] vs. 222 [47 to 483] ml, p = 0.049) and correlated with improved oxygenation (R² = 0.45, p = 0.002). Two and seven patients in the Express and P_L,expi groups, respectively, had P_L,EL > 25 cmH₂O.

There is a great heterogeneity of P_Lexpi when P_plat is used to titrate PEEP but with limited risk of over-distension. A PEEP titration for a moderate positive level of P_Lexpi might slightly improve alveolar recruitment and oxygenation but increases the risk of over-distension in one-third of patients.