Nature beyond control: how expectations should inform decisions about human germline engineering

Area of Science:

• Bioethics
• Psychology
• Genetics

Background:

• Reproductive human germline modification is a topic of ethical debate.
• Its potential impact on psychological well-being remains underexplored.
• Existing discussions often overlook the psychological implications for all parties involved.

Purpose of the Study:

• To examine the potential psychological consequences of human germline modification.
• To assess whether germline engineering aligns with theories of psychological well-being.
• To explore the psychological risks for parents, society, and the genetically modified individual.

Main Methods:

• Theoretical analysis drawing on psychological theories.
• Application of self-discrepancy theory.
• Application of relative deprivation theory.

Main Results:

• Germline engineering may foster unrealistic expectations of genetic control.
• Limited understanding of gene-environment interactions can lead to unmet expectations.
• Both editing and being edited could result in negative emotional states.

Conclusions:

• Psychological well-being may not be enhanced by germline modification.
• Unmet expectations from genetic control attempts could outweigh intended benefits.
• Further consideration of psychological impacts is crucial for germline editing discussions.