Related Experiment Video

Updated: Jan 22, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis

Yan Wang1, Wei Li2, Jun Yang3

  • 1Xi'an Medical University, No 74 Hanguangbei Road, Xi'an, 710068, Shaanxi, China.

Journal of Molecular Neuroscience : MN
|July 18, 2019
PubMed

Insights

Elevated cystatin C levels are linked to a higher risk of ischemic stroke. This finding suggests cystatin C may serve as a valuable biomarker for predicting stroke risk, particularly in acute cases.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Biomarker Research

Background:

  • Ischemic stroke significantly impacts patient health and quality of life.
  • Cystatin C is emerging as a potential biomarker for cardiovascular diseases.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between cystatin C and ischemic stroke risk.
  • To evaluate cystatin C as a predictor for ischemic stroke, especially in acute and subclinical forms.

Main Methods:

  • A systematic literature search was conducted for studies examining cystatin C and ischemic stroke.
  • A random-effects meta-analysis was performed on data from nine studies.
  • Included were 3773 patients with ischemic stroke and control participants.

Main Results:

  • Patients with ischemic stroke exhibited significantly higher serum cystatin C concentrations (pooled mean difference: 0.11; 95% CI: 0.00–0.22; P=0.04).
  • Elevated cystatin C was particularly noted in acute ischemic stroke (mean difference: 0.23; 95% CI: 0.11–0.36; P=0.0003).
  • Higher cystatin C levels were also associated with subclinical cerebral infarction (mean difference: 0.07; 95% CI: 0.05–0.09; P<0.00001).

Conclusions:

  • Cystatin C is significantly associated with an increased risk of ischemic stroke.
  • Cystatin C demonstrates potential as a predictive biomarker for ischemic stroke.
  • The predictive value of cystatin C is especially pronounced in acute ischemic stroke and subclinical cerebral infarction.

Keywords:
Cystatin CIschemic strokeMeta-analysisRisk

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.5K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.5K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
12.7K