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Rosette-forming glioneuronal tumor: an update.

C T Anyanwu1,2, T M Robinson3, J H Huang4,3

  • 1Texas A&M Health Science Center College of Medicine, 8447 State Highway 47, Bryan, TX, 77807, USA. chi2ag@yahoo.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|July 18, 2019
PubMed
Summary

Rosette-forming glioneuronal tumors (RGNTs) are rare, benign nervous system neoplasms. Comprehensive review of recent literature characterizes their symptoms, imaging, treatment, and prognosis, aiding clinical understanding.

Keywords:
BenignBrain tumorCerebellar massPosterior fossa neoplasmRGNTRosette-forming glioneuronal tumor

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Area of Science:

  • Neurology
  • Neuro-oncology
  • Pathology

Background:

  • Rosette-forming glioneuronal tumor (RGNT) is a rare primary nervous system neoplasm.
  • Existing literature is sparse, with limited case reports and outdated reviews.

Purpose of the Study:

  • To provide a comprehensive review of recent literature on RGNTs.
  • To characterize presenting symptoms, radiological findings, treatment strategies, and prognosis.

Main Methods:

  • Medline search for case reports of primary RGNTs.
  • Synthesis of recent literature to consolidate key characteristics.

Main Results:

  • RGNTs are benign, indolent tumors with glial and neurocytic components.
  • Common symptoms include headaches and visual disturbances; frequent locations are the fourth ventricle and cerebellum.
  • Surgical gross total resection (GTR) is associated with a better prognosis.

Conclusions:

  • RGNTs are rare tumors requiring updated characterization.
  • Timely diagnosis and surgical management, particularly GTR, are crucial for favorable outcomes.