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[Participation of suppressor cells in the depressing action of serotonin on immunogenesis]
The transfer of 20 x 10(6) T and B cells of lymphoid organs from the donors immunized with sheep erythrocytes and having elevated serotonin level to the recipients immunized with SRBC decreased the intensity of immune response (rosette formation and direct plaque formation). The elevation of serotonin level in the donors induced the appearance of T and B suppressors in the thymus and the bone marrow respectively and increased the population of T and B suppressors in the spleen and, to a lesser extent, in lymph nodes.
The transfer of 20 x 10(6) T and B cells of lymphoid organs from the donors immunized with sheep erythrocytes and having elevated serotonin level to the recipients immunized with SRBC decreased the intensity of immune response (rosette formation and direct plaque formation). The elevation of serotonin level in the donors induced the appearance of T and B suppressors in the thymus and the bone marrow respectively and increased the population of T and B suppressors in the spleen and, to a lesser extent, in lymph nodes.