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Updated: Oct 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

[Participation of suppressor cells in the depressing action of serotonin on immunogenesis]

L V Devoĭno, N B Morozova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |May 1, 1979
    PubMed

    The transfer of 20 x 10(6) T and B cells of lymphoid organs from the donors immunized with sheep erythrocytes and having elevated serotonin level to the recipients immunized with SRBC decreased the intensity of immune response (rosette formation and direct plaque formation). The elevation of serotonin level in the donors induced the appearance of T and B suppressors in the thymus and the bone marrow respectively and increased the population of T and B suppressors in the spleen and, to a lesser extent, in lymph nodes.

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